Prep SFC 50

Preparative Scale Separation – Compact Design

The Prep SFC 50 from Sepiatec is a compact and easy-to-use chromatography system for preparative separations on small columns by means of supercritical fluid chromatography (SFC).

The system offers the comprehensive benefits of SFC technology, such as faster separations, lower costs due to reduced consumption of organic solvents, as well as being more environmentally friendly at increased safety.

The Prep SFC 50 is equipped with two 400 bar high-pressure pumps with 30 ml pump heads. The total flow – at a modifier portion of 40 % - amounts to 50 ml/min. This way, chromatography columns with inner diameters ranging from 4 to 16 mm, and a length of 250 mm can be used.

The column oven, containing the chromatography columns together with the injection valve and the UV flow cell, is heatable up to 70° C so that a uniform temperature is ensured. The Prep SFC 50 system is available with 8 gas-liquid-separators.

As fractions are collected in unpressurized state, not only safety is increased, but also handling is simplified, and limitations with respect to the size of fraction volumes do not exist. This option proves to be extremely convenient when working with stack injections.

As the dimensions of the Prep SFC 50 together with the integrated system controller and 15.6” touch screen amount to only 56 x 60 x 88 cm (W x D x H) this system requires a minimum of space in the laboratory. A separate computer or monitor is not necessary.

The equipment of the Prep SFC 50 system includes:

• a high pressure pump for CO2
• a high pressure pump for modifiers
• an adjustable back pressure regulator
• a syringe pump for sample injection
• a UV detector
• an integrated system controller
• a 15.6“ touch screen
• USB connectors, Ethernet and HDMI connector
• the Prep SFC control software

Operating mode 1 analytical or semi-preparative column
Solvents CO2 and organic solvents
Number of modifier solvents 1 standard, max. 4 solvents with optional selection valve
Total flow rate 50 ml/min at a modifier portion of 40 %
CO2 pump 30 ml pump head, 400 bar
Modifier pump 30 ml pump head, 400 bar
Add - on pump 10 ml pump head, 400 bar (optional)
Operating pressure Up to 300 bar, back pressure regulator online adjustable
Injection Partial loop with syringe pump
Column Oven Ambient temperature to 70° C, 2 columns standard,   6 columns with optional valves
UV detector Wavelength range 190 to 500 nm
Number of fractions 1 to 8 fractions, unlimited volumes, pressure-less collection
Software Prep SFC control software
System controller Integrated controller, Windows 10
Connections 3 USB ports, Ethernet, HDMI
Dimensions 56 x 60 x 88 cm (W x D x H)


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