Prep SFC M5

Versatile SFC System for Chiral and Achiral Separations

Sepiatec’s Prep SFC M5 system is a preparative system for separating chiral and achiral samples using supercritical fluid chromatography.

The Prep SFC M5 system consists of the main module and the collector module. Both modules form a functional unit that can be configured in a variety of ways with different equipment.

The main module can be equipped with up to three high pressure pumps, a CO2 pump, a modifier pump and an optional add-on pump for separations with low modifier portions. The available options include CO2 and modifier pumps with 30 ml pump heads, 400 bar (Prep SFC M5-50) or CO2 and modifier pumps with 150 ml pump heads, 400 bar (Prep SFC M5-250).

The integrated auto sampler can accommodate two standard or two deep well microtiter plates with 24 wells and a volume of 10 ml each or racks with up to 60 sample vials with a volume of 1.5 ml each.

The heatable column oven contains up to 10 separation columns with internal diameter of 4 to 30 mm and a length of 250 mm.

Standard equipment in the main module is a UV detector for measuring in the range of 190 – 500 nm. Other detectors, such as a DAD or an ELSD, can also be connected.

An integrated system controller and a 15.6” TFT touch screen are used to input all data for sample separations. No additional computer is needed, reducing the space required for the Prep SFC M5 system to a width of just 92 cm.

The post heater and the back pressure regulator are integrated within the collector module. The continuously operating gas-liquid separator is located at the front of the collector module; it removes residual CO2 from the isolated compounds.

The Prep SFC M5 system can be fitted with a carousel fraction collector which can accommodate collection vessels with volumes ranging from 10 to 500 ml.

Alternatively, an XY-fraction collector for vials with volumes of 10 or 60 ml is available. A total of up to 195 fractions can be collected.


Solvents CO2 and organic solvents
Number of modifier solvents 1 standard, max. 4 with optional selection valve
Operating pressure Up to 300 bar, back pressure regulator online adjustable
Autosampler 2 standard microtiter plates or 2 deep well MTP with 24 wells 10 ml each, racks with 60 vials 1.5 ml or 24 vials 5 ml each
Injection Partial loop with syringe pump
Column oven Ambient temperature to 70° C, 10 columns
UV detector Wavelength range 190 to 500 nm
Other detectors DAD, ELSD or mass spectrometer optional
Fraction collectors Carousel fraction collector: fraction volumes 10 to 500 ml
XY-fraction collector: 72 vials 60 ml or 195 vials 10 ml,
custom made fraction collectors available on request
Software Prep SFC control software
System controller Integrated controller, Windows 10
Touch screen 15.6” touch screen, 16:9 format
Connections 3 USB ports, Ethernet, HDMI
Dimensions 92 x 60 x 88 cm (W x D x H), with XY fraction collector 97 cm in width


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